Question 1

How can I align GWAS summary statistics?

Accepted Answer

Upload a GWAS summary-statistics file, confirm the detected columns and genome build, select the required allele, build, and rsID options, inspect the harmonisation preview, and export the aligned result.

Question 2

What does GWAS Harmoniser align?

Accepted Answer

GWAS Harmoniser standardises common summary-statistics columns and supports reference, alternate, effect, and non-effect allele handling, build-aware coordinate workflows, rsID checks, and consistent export preparation.

Question 3

Can GWAS Harmoniser prepare sumstats for meta-analysis?

Accepted Answer

GWAS Harmoniser can standardise fields and help align alleles, coordinates, and identifiers before cross-study comparison or meta-analysis. Researchers must still verify cohort metadata, analysis models, genome-build provenance, and study-specific quality-control requirements.

Question 4

Does GWAS Harmoniser support genome-build liftover?

Accepted Answer

GWAS Harmoniser supports build-aware processing and liftover workflows so coordinates can be prepared consistently when source and target reference assemblies differ.

Question 5

Does GWAS Harmoniser support large GWAS files?

Accepted Answer

The application is designed around reliable uploads, preview generation, background download preparation, and polling for large GWAS summary-statistics files.

Question 6

Who should use GWAS Harmoniser?

Accepted Answer

GWAS Harmoniser is intended for researchers, geneticists, statistical geneticists, epidemiologists, and bioinformaticians preparing GWAS summary statistics for downstream analysis.